Sqlite DB in google drive folder

Hi all,
is it possible (secure) to save a Sqlite DB in google drive folder so that is possible to open from different Macs not located in the same wired network?

No.

don’t do that, or you will lose the sqlite file integrity.
use cubesql to share the sqlite file
or share your database with another free dbserver like postgresql.

Unwise. See:

https://www.sqlite.org/howtocorrupt.html

and read sections 2 and 3.

If you really want to share an SQLite database with multiple users/devices, the best way to do this is to use CubeSQL which can be found here:

https://sqlabs.com/cubesql

Sharing an SQLite database is the raison d’etre for the CubeSQL product.