I would think the whole front end engine of the Web Framework would need to be redone to get anywhere close to what you’re hoping for. We know that it’s a hot mess right now because the original concept was a web version of desktop interfaces.
It might be helpful to look at how the Stacks RapidWeaver plugin does it’s design concepts, but I haven’t honestly looked at that in years so I couldn’t say if it’s a good or bad idea.
Plus, what do we do for the folks who do want a web version of desktop interfaces? I think corporate web apps prefer the desktop interface approach having used several different webapps for a few different companies in the past.