I have tested and used Enigma VirtualBox with Xojo Web apps and everything works correctly. It moves any file into a virtual drive. Can also include registry entries. Is free but paid version allows more features
https://enigmaprotector.com/en/aboutvb.html
Application virtualization system for Windows. Enigma Virtual Box enables application files and registry to be consolidated in a single executable file, without loss of efficiency and without virtualized files having to be extracted to the HDD. Enigma Virtual Box is a free application that supports both x86 and x64 binaries.
Paid version below with extra features