That’s weird from the Xojo perspective, as he is setting all the values, but… if he was using a mysql.exe tool without an user specified (like mysql.exe -u root), the mysql.exe assumes -u ODBC in Windows.
You need to contact Xojo.
If you can create a sample project that works on 2025r1.1 but not with 2025r2 will be best.
You can contact support by email.
I see you create an Issue: #79521 - Error 1045 Xojo 2025r2
but is missing some basic information like: