To open the UB apps in Big Sur is not the problem - this works fine here. Its 10.11 up to 10.14 where the problem appears (on my test machines and apparently on Sams).
Thanks for testing and confirming the error - hope its easier to find the reason if more people are able to reproduce it…
I tried your app on macOS 10.11.6 and got the following error:
Location: Common/plugin.cpp:1048
Condition: false
Message: Could not open plugin MBS_MacBase_NSAttributedString_Plugin_20393.dylib (dlopen(/Volumes/Ausbruch/Ausbruch.app/Contents/Frameworks/MBS_MacBase_NSAttributedString_Plugin_20393.dylib, 5): no suitable image found. Did find:
/Volumes/Ausbruch/Ausbruch.app/Contents/Frameworks/MBS_MacBase_NSAttributedString_Plugin_20393.dylib: no matching architecture in universal wrapper)
Xojo’s own plugins (e.g. the MySQL Community Plugin) work fine in a UB app, even under 10.11. Maybe you can find out if and where there is a difference between their plugins and yours?