Absolutely worth it, all other major development systems have had 64bit for years, on Mac & Linux 64bit is THE standard. The only place 32bit is appropriate at this stage is on embedded micro-controllers. MS has a great 32bit compatibility layer, but that is just a stop gap to get to 64bit.
We stopped using Xojo after more than a decade of use ( REAL/Xojo ) because of the lack of 64bit support and being able to ship Xojo based object libs. With some limited 64bit support now, we are taking another look.
There aren’t shipping 32bit desktop processors, all Intel, AMD, and a good portion of ARM are 64bit. Again 32bit is a great embedded controller, but if you aren’t doing 64bit, you have already lost the race.