On 1 specific Windows 10 PC in my organization, a Xojo Desktop app utilizing the new DateTime class would crash at DateTime.Now. This was found during a Remote Debugger session. The error is "Xojo.Core.InvalidArgumentException" with message "Bad Timezone name".
On the system that was not working, I went to the Windows 10 Time Zone settings and it was set to "Central Time (USA and Canada)". I changed it to "Central America" and the Xojo app no longer crashed. I then set it back to "Central Time (USA and Canada)" and the Xojo app still works without crashing. Go figure.
I am posting this on the forum in case someone else runs into this.