When is correct time to set SQLite MultiUser?

Hello all

In this thread
link text

Greg provides a statement like “Well one thing is that multiuser should be set before you connect…”
My question is - is Greg correct or are the docs correct or does it not matter?

I ask since I too have problem occassionally with the app not quiting, or going to the new URL but right back to the login screen.

Thanks,
Timi