Forbids JavaScript from accessing the cookie, for example, through the Document.cookie property. Note that a cookie that has been created with HttpOnlywill still be sent with JavaScript-initiated requests, for example, when calling XMLHttpRequest.send() or fetch(). This mitigates attacks against cross-site scripting (XSS).
Any idea what that would mean in the context of a Xojo WebApp?
Yeah, for one thing, it means that any third party controls or libraries on the page would not be able to read the contents of the cookies when they send data to the back end, which could potentially be a security risk if you were storing some sort of connection token in a cookie.