No reaction to menu shortcuts

Why does my app do nothing when I click a menu short cut? Example projects work fine. But in my app nothing happens. This even shows up for built the built app.

Xojo 2020r2.1 on M1.

Correction: in the built app the menu short cuts sometimes work and sometimes they don’t.

I see this in the IDE occasionally.

Usually it’s the keyboard sequence for a run remotely (command option R ) which stops working. I wonder if this is related?

Yes, I have seen that for quite a while. But this is the app in the debugger and the built one. The whole day the shortcuts didn’t work and now they work again. Gr…