I was working with comics front cover, resizing them, yesterday when I falled on this one.
On left, the resized cover with Preview (OS X 10.8.5), on the right, resized using Xojo (current).
It also happens (similar to worst result) with some 2000AD cover scans.
PS: In a project, I generate five size (different names and usages, of course), two goes into two different folders created on purpose in the drop image folder. I automated the process as far as I can do, but if I have to do it manually I will fall into a different bug (in an older application, I place the resized image in Image and its file name in RAW as text; and on some occasions, the text is cleared from the Clipboard )